@eugenmayer I think that sync solutions are great for a good number of use cases. For my engineers, since they have to be able to work on quite a number of fully different code bases, this can start putting the files to sync into 250k range.
As far as drush, we have to bootstrap it with a wrapper script to work with some of our performance enhancements. The uli command takes about 5 seconds, cc takes about 10 secs.