Docker MultiHost Networking: Change Registry?

I am wondering if it is possible to change the registry of docker multihost networking? The new registry should have the same network settings. Is that possible?

Background: I’d like to wire up a zero operational downtime deployment with two EC2 instances.

EC2-1: application services
EC2-2: database and consul registry for docker networking

Services of EC2-1 would talk to the database over a docker multihost network. Problem: What if I want to replace EC2-2 with a fresh one?