Can we attach docker customize interfaces with any physical NIC

For example, our physical server has 2 NICs and both are active.
1- With which docker0 will be connected?
2- If we create a and interface, can we attach it with any NIC of our choice.

Its possible to replace default docker0 bridge with your own bridge. You can add any physical NIC to your bridge.
Also configure docker daemon to use your bridge as default bridge instead of docker0 when containers are created.